| Autor: |
Zachary A. Matthay, Alexander T. Fields, Katherine D. Wick, Chayse Jones, H. Clifford Lane, Kimberly Herrera, Brenda Nuñez-Garcia, Efstathios Gennatas, Carolyn M. Hendrickson, Aaron E. Kornblith, Michael A. Matthay, Lucy Z. Kornblith, the COVID-19 Associated Coagulopathy Inflammation Thrombosis (Co-ACIT) Study Group, Biniam Ambachew, Roland J. Bainton, Sarah Cary, Lauren Chalwell, Christopher Colwell, Clayton Josephy, Philip Kurien, Deanna Lee, Matthieu LeGrand, Juan Carlos Montoy, Viet Nguyen, John J. Park, Arun Prakash, Brittany Robinson, Shelley India |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 14 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2023.1130821 |
| Popis: |
IntroductionThere remains a need to better identify patients at highest risk for developing severe Coronavirus Disease 2019 (COVID-19) as additional waves of the pandemic continue to impact hospital systems. We sought to characterize the association of receptor for advanced glycation end products (RAGE), SARS-CoV-2 nucleocapsid viral antigen, and a panel of thromboinflammatory biomarkers with development of severe disease in patients presenting to the emergency department with symptomatic COVID-19.MethodsBlood samples were collected on arrival from 77 patients with symptomatic COVID-19, and plasma levels of thromboinflammatory biomarkers were measured.ResultsDifferences in biomarkers between those who did and did not develop severe disease or death 7 days after presentation were analyzed. After adjustment for multiple comparisons, RAGE, SARS-CoV-2 nucleocapsid viral antigen, interleukin (IL)-6, IL-10 and tumor necrosis factor receptor (TNFR)-1 were significantly elevated in the group who developed severe disease (all p80% on cut-point analysis.DiscussionElevated RAGE and SARS-CoV-2 nucleocapsid viral antigen on emergency department presentation are strongly associated with development of severe disease at 7 days. These findings are of clinical relevance for patient prognostication and triage as hospital systems continue to be overwhelmed. Further studies are warranted to determine the feasibility and utility of point-of care measurements of these biomarkers in the emergency department setting to improve patient prognostication and triage. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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