Transcription factor ZNF148 is a negative regulator of human muscle differentiation

Autor:	Jesse Bakke, William C. Wright, Anthony E. Zamora, Su Sien Ong, Yue-Ming Wang, Jessica D. Hoyer, Christopher T. Brewer, Paul G. Thomas, Taosheng Chen
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Medicine Science
Zdroj:	Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Druh dokumentu:	article
ISSN:	2045-2322 05810787
DOI:	10.1038/s41598-017-08267-5
Popis:	Abstract Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5d4c2271ee054f058107877188025ae7 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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