An integrated model for detecting significant chromatin interactions from high-resolution Hi-C data

Autor: Mark Carty, Lee Zamparo, Merve Sahin, Alvaro González, Raphael Pelossof, Olivier Elemento, Christina S. Leslie
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms15454
Popis: Genome-wide chromosome conformation capture has helped us identify features of genome topology influencing biology but requires careful statistical analysis. Here the authors present HiC-DC, a bioinformatics method that can detect statistically significant regulatory interactions.
Databáze: Directory of Open Access Journals