Rejuvenation of Mesenchymal Stem Cells to Ameliorate Skeletal Aging

Autor: Mingjia Cheng, Weihao Yuan, Alireza Moshaverinia, Bo Yu
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Cells, Vol 12, Iss 7, p 998 (2023)
Druh dokumentu: article
ISSN: 12070998
2073-4409
DOI: 10.3390/cells12070998
Popis: Advanced age is a shared risk factor for many chronic and debilitating skeletal diseases including osteoporosis and periodontitis. Mesenchymal stem cells develop various aging phenotypes including the onset of senescence, intrinsic loss of regenerative potential and exacerbation of inflammatory microenvironment via secretory factors. This review elaborates on the emerging concepts on the molecular and epigenetic mechanisms of MSC senescence, such as the accumulation of oxidative stress, DNA damage and mitochondrial dysfunction. Senescent MSCs aggravate local inflammation, disrupt bone remodeling and bone-fat balance, thereby contributing to the progression of age-related bone diseases. Various rejuvenation strategies to target senescent MSCs could present a promising paradigm to restore skeletal aging.
Databáze: Directory of Open Access Journals
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