Seminal Histone Deacetylase, Fructose and Serum Reproductive Hormones as Diagnostic Marker in Sub-Groups of Infertile Males

Autor: Wasiu Eniola Olooto, Hammed A Adenusi, Joseph O Soola, Monisola A Ayodele, Frank E Agidigbi
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Acta Medica Iranica, Vol 61, Iss 4 (2023)
Druh dokumentu: article
ISSN: 0044-6025
1735-9694
DOI: 10.18502/acta.v61i4.13170
Popis: Accurate diagnosis of the cause of infertility assists in the choice of treatment modalities and amelioration of the associated psychosocial problems. The research was carried out using 75 infertile males and 75 males with proven fertility as controls. The anthropometrics (weight, height) were measured and body mass index (BMI) computed. Venous blood was collected from each participant, allowed to clot, and centrifuged to obtain the serum which was analysed for testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) concentrations. Semen was collected by masturbation and analysed for sperm quality, seminal fructose concentration, and histone deacetylase (HDAC) activities. A non-significant difference (P>0.05) in weight, height, and BMI; a significant increase (P
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