CHARACTERISTICS OF CEREBRAL TOXLOPLASMOSIS IN HIV PATIENTS: RETROSPECTIVE ANALYSIS OF 135 CASES IN DNIPROPETROVSK REGION

Autor: L. R. Shostakovych-Koretska, K. Yu. Lytvyn, O. О. Volikova, О. О. Bilokon, І. P. Mishkoy, Z. О. Chykarenko, O. A. Kushnierova, S. A. Halushchenko
Jazyk: ukrajinština
Rok vydání: 2018
Předmět:
Zdroj: Vіsnik Naukovih Doslіdžen', Vol 0, Iss 4 (2018)
Druh dokumentu: article
ISSN: 1681-276X
2415-8798
DOI: 10.11603/2415-8798.2017.4.8404
Popis: From 40 to 70 % of patients with HIV have neurological disorders. Toxoplasmosis is one of the most common causes of brain damage in patients with HIV, which often leads to mortality. The aim of the study – to determine and compare the main characteristics of the central nervous system toxoplasmosis in HIV-positive patients who had different outcome of the disease (survived or died as a result of the disease). Materials and Methods. A retrospective cohort analysis of 135 cases of cerebral toxoplasmosis in HIV-positive patients in the Dnipropetrovsk region (Ukraine) from 2010 to 2017 was conducted. The presence of toxoplasmosis was confirmed by the detection of DNA of Toxoplasma gondii in the cerebrospinal fluid, and in the dead patients, the study of autopsy material was performed. Statistical processing of the results of the study was conducted using STAT IST ICA v.6.1® and SPSS programs. In order to compare the indicators in the groups of patients who died and those who survived, odds ratios (OR s) were calculated with confidence intervals (95 % CI). Results and Discussion. Toxoplasmosis was diagnosed in 30 % of HIV-positive patients with CNS disordrers. Most of the patients were males – 71 (52.6 %), the average age was 37.79±0.64. The number of fatal cases was 29 (21.5 %). The groups of patients who survived or died did not differ significantly in age ((37.47±0.72) versus (38.93±1.46) years)) (p>0.05) and gender composition (male 53.8 % vs. 48.3 % of women). Sexually transmitted infections occurred in 40.0 % of cases, because of injecting drug use (IDU s) – 34.8 %, the infection route was uncertain in 25.2 %. In the dead, the uncertain route of infection was 51.7 % versus 17.9 % (p
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