Comparison of chemotherapy outcomes between normal and high serum cortisol concentration in dogs with lymphoma

Autor:	Hiroki Yamazaki, Kaito Bunbai, Tatsuya Deguchi, Masahiro Tamura, Hiroshi Ohota
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	endogenous corticosteroid glucocorticoid receptor glucocorticoid resistance P‐glycoprotein Veterinary medicine SF600-1100
Zdroj:	Journal of Veterinary Internal Medicine, Vol 38, Iss 3, Pp 1651-1658 (2024)
Druh dokumentu:	article
ISSN:	1939-1676 0891-6640
DOI:	10.1111/jvim.17044
Popis:	Abstract Background Increased serum cortisol (COR) concentrations may induce glucocorticoid resistance by down‐regulation of glucocorticoid receptor (GCR), resulting in decreased chemotherapy efficacy in dogs with lymphoma. Hypothesis Investigate the relationship between serum COR concentrations and chemotherapy outcomes in dogs with lymphoma. Animals Thirty client‐owned dogs with lymphoma, with serum COR concentration measured using serum samples collected at diagnosis. Methods Retrospective study. Dogs were divided into 2 groups based on serum COR concentrations: a normal group (n = 16) with COR concentrations
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5d3842fc3e3448cb9e5b56f26d9d4ce8 Zobrazit plný text záznamu Plný text View record in DOAJ