The Transmembrane Mucin MUC1 Facilitates β1-Integrin-Mediated Bacterial Invasion

Autor: Xinyue Li, Richard W. Wubbolts, Nancy M. C. Bleumink-Pluym, Jos P. M. van Putten, Karin Strijbis
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: mBio, Vol 12, Iss 2 (2021)
Druh dokumentu: article
ISSN: 2150-7511
DOI: 10.1128/mBio.03491-20
Popis: Bacteria can exploit membrane receptor integrins for cellular invasion, either by direct binding of bacterial adhesins or utilizing extracellular matrix components. MUC1 is a large transmembrane glycoprotein expressed by most epithelial cells that can have direct defensive or receptor functions at the host-microbe interface and is involved in facilitating integrin clustering.
Databáze: Directory of Open Access Journals