| Autor: |
Laura Naranjo, Ljudmila Stojanovich, Aleksandra Djokovic, Laura Andreoli, Angela Tincani, Maria Maślińska, Savino Sciascia, Maria Infantino, Sara Garcinuño, Kinga Kostyra-Grabczak, Mariangela Manfredi, Francesca Regola, Natasa Stanisavljevic, Milomir Milanovic, Jovica Saponjski, Dario Roccatello, Irene Cecchi, Massimo Radin, Maurizio Benucci, Daniel Pleguezuelo, Manuel Serrano, Yehuda Shoenfeld, Antonio Serrano |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Frontiers in Immunology, Vol 13 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2022.957201 |
| Popis: |
BackgroundAntiphospholipid syndrome (APS) is a multisystemic autoimmune disorder characterized by thrombotic events and/or gestational morbidity in patients with antiphospholipid antibodies (aPL). In a previous single center study, APS-related clinical manifestations that were not included in the classification criteria (livedo reticularis, thrombocytopenia, leukopenia) were associated with the presence of circulating immune-complexes (CIC) formed by beta-2-glycoprotein-I (B2GP1) and anti-B2GP1 antibodies (B2-CIC). We have performed a multicenter study on APS features associated with the presence of B2-CIC.MethodsA multicenter, cross-sectional and observational study was conducted on 303 patients recruited from six European hospitals who fulfilled APS classification criteria: 165 patients had primary APS and 138 APS associated with other systemic autoimmune diseases (mainly systemic lupus erythematosus, N=112). Prevalence of B2-CIC (IgG/IgM isotypes) and its association with clinical manifestations and biomarkers related to the disease activity were evaluated.ResultsB2-CIC prevalence in APS patients was 39.3%. B2-CIC-positive patients with thrombotic APS presented a higher incidence of thrombocytopenia (OR: 2.32, p=0.007), heart valve thickening and dysfunction (OR: 9.06, p=0.015) and triple aPL positivity (OR: 1.83, p=0.027), as well as lower levels of C3, C4 and platelets (p-values: |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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