| Autor: |
Ji-Ae Hong, Hae-ju Ko, Kyo-Nyeo Oh, Moonjong Kim, Jung-Soon Mo, Chul Yung Choi, Ki-Man Kim, Donghyuk Bae |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Photochemistry and Photobiology, Vol 20, Iss , Pp 100228- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-4690 |
| DOI: |
10.1016/j.jpap.2024.100228 |
| Popis: |
Ultraviolet (UV) irradiation has been identified as a key trigger for skin photoaging, characterized by the overproduction of matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), along with the accelerated decomposition of extracellular matrix (ECM) proteins, ultimately contributing to the development of wrinkles. Persicaria senticosa (PS) extracts are recognized for their antioxidative properties and their importance in skin health. Nevertheless, there is a paucity of studies investigating the potential of PS in protecting the skin against photoaging. The present study aimed to assess the effectiveness of PS extracts in preventing photoaging and elucidating the molecular mechanisms involved in using immortalized human keratinocytes (HaCaT) and hairless mice. The major bioactive constituents of PS were identified as p-coumaric acid, isoquercitrin, quercetin-3-O-glucuronide, and quercetin. Aqueous extracts of PS exhibited the ability to mitigate UVB-induced cellular damage and diminished ROS generation in HaCaT cells. Moreover, treatment with PS effectively attenuated the upregulated expression of matrix metalloproteinase-1 (MMP-1) and collagen degradation induced by UVB exposure. The property of PS to counteract photoaging was related to its capacity to inhibit the UVB-induced phosphorylation of mitogen-activated protein kinase (MAPK) and suppress the subsequent activation of activator protein 1 (AP-1) signaling pathways. Moreover, in hairless mice exposed to UVB radiation, the application of PS significantly alleviated the development of skin wrinkles, diminished epidermal thickening, and mitigated collagen degradation. Notably, PS treatment resulted in the downregulation of the UVB-activated MAPK/AP-1/MMP-1 pathway in mouse skin tissues. These findings suggest that PS has the potential to serve as a therapeutic agent for treating photoaging, holding promises in both cosmeceutical and pharmaceutical applications. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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