A case of spontaneous intracranial hypotension in a 45-year-old male with headache, behavior changes and altered mental status

Autor: Sukhman Kaur, MD, Kihyun Kwon, MD, Sudha Ramachandran, MD, Leszek Pisinski, MD, Alan Krauthamer, MD
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Radiology Case Reports, Vol 17, Iss 7, Pp 2289-2294 (2022)
Druh dokumentu: article
ISSN: 1930-0433
DOI: 10.1016/j.radcr.2022.03.075
Popis: Spontaneous intracranial hypotension is a rare disease that results from low cerebrospinal fluid (CSF) volume caused by leakage of CSF from the spine in the absence of lumbar puncture, spine surgery, or intervention. The most common presentation is the headache that is usually but not invariably orthostatic. The underlying pathology is a CSF leak resulting from dural weakness involving the nerve root sleeves, ventral dural tears associated with calcified disc herniations, or CSF venous fistula. In severe cases, neuropsychiatric symptoms and changes in mental status may develop. Some case reports also mention gait disturbances, slurred speech, and urinary incontinence. The constellation of neuropsychiatric symptoms similar to behavior variant frontotemporal dementia in the presence of “brain sag” on MRI is known as frontotemporal brain sagging syndrome, first described by Wicklund et al. (4). The disease presents a diagnostic challenge to the primary care physicians, who are the first to see these patients. Brain and spine imaging is key to diagnoses but requires a high index of suspicion, as very rarely are all classic findings of intracranial hypotension present in the same patient. Here we discuss a case of spontaneous intracranial hypotension in a 45-year-old male patient who presented with headache, drowsiness, incoherent speech, behavior symptoms, and altered mental status.
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