| Popis: |
Background Previous studies have shown various improvement effects of non-invasive brain stimulation (NIBS) on autism spectrum disorder (ASD), and there is a lack of comparison of the efficacy of different types of NIBS. Objective To systematically evaluate the effect of NIBS on ASD, and to compare the curative effects of two types of NIBS. Methods Randomized controlled trials (RCTs) about the effect of NIBS on ASD〔both experimental and control groups received conventional treatments, and the experimental group additionally received transcranial direct current stimulation (tDCS) or repetitive transcranial magnetic stimulation (rTMS) 〕 were retrieved from databases of PubMed, Embase, Cochrane Library, Scopus, Web of Science, CNKI, Wanfang Data, CQVIP, and SinoMed from inception to December 2021. Two researchers independently implemented literature screening and data extraction, and used the Cochrane Handbook for Systematic Reviews of Interventions (version 5.1.0) to assess the risk of bias of the included studies. The statistical analysis was performed using RevMan 5.3 and R 4.0.2. Results Ultimately, 22 studies involving 661 patients were included. Meta-analysis showed that NIBS could reduce Autism Behavior Checklist (ABC) score 〔MD=-8.80, 95%CI (-10.98, -6.62), PrTMS (P=0.069) . Conclusion Existing evidence shows that NIBS can improve ASD, and the effect of tDCS is better than that of rTMS. |
