Hovendulcisic acid A-D: four novel ceanothane-type triterpenoids from Hovenia dulcis stems with anticancer properties

Autor: Jianzhan Yang, Wanna Cai, Fan Wu, Shengmei Xu, Xiaoqi Zhang, Bo Liu, Fangfang Xu
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Chemistry, Vol 12 (2024)
Druh dokumentu: article
ISSN: 2296-2646
DOI: 10.3389/fchem.2024.1383886
Popis: Sixteen ceanothane-type triterpenoids, including four new compounds—hovendulcisic acids A–D (1–4) —were purified from the stems of Hovenia dulcis Thunb. The structures of 1–4 were confirmed by comprehensive means including ECD and quantum chemical calculations. Putative biosynthetic pathways of 1–16 were proposed, and 3, 5, and 15 exhibited antitumor activity on A549 and MDA-MB-231 cells.
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