Further evidence that CP-AMPARs are critically involved in synaptic tag and capture at hippocampal CA1 synapses

Autor:	Pojeong Park, Heather Kang, John Georgiou, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Synaptic tag and capture Synapse specificity Synaptic efficacy Synaptic potentiation Heterosynaptic plasticity Metaplasticity Neurology. Diseases of the nervous system RC346-429
Zdroj:	Molecular Brain, Vol 14, Iss 1, Pp 1-8 (2021)
Druh dokumentu:	article
ISSN:	1756-6606
DOI:	10.1186/s13041-021-00737-2
Popis:	Abstract The synaptic tag and capture (STC) hypothesis provides an important theoretical basis for understanding the synaptic basis of associative learning. We recently provided pharmacological evidence that calcium-permeable AMPA receptors (CP-AMPARs) are a crucial component of this form of heterosynaptic metaplasticity. Here we have investigated two predictions that arise on the basis of CP-AMPARs serving as a trigger of STC. Firstly, we compared the effects of the order in which we delivered a strong theta burst stimulation (TBS) protocol (75 pulses) and a weak TBS protocol (15 pulses) to two independent inputs. We only observed significant heterosynaptic metaplasticity when the strong TBS preceded the weak TBS. Second, we found that pausing stimulation following either the sTBS or the wTBS for ~20 min largely eliminates the heterosynaptic metaplasticity. These observations are consistent with a process that is triggered by the synaptic insertion of CP-AMPARs and provide a framework for establishing the underlying molecular mechanisms.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5ce3056a859b49ee950ff08c0cb6d9b2 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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