A Cerebellar High-Grade Neuroepithelial Tumour with BCOR Alteration in a five-year-old Child: A case report
| Autor: | Abeer Al-Battashi, Zahra Al Hajri, Arie Perry, Hunaina Al-Kindi, Ibrahim Al-Ghaithi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Sultan Qaboos University Medical Journal, Vol 19, Iss 2, Pp 153-156 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2075-051X 2075-0528 |
| DOI: | 10.18295/squmj.2019.19.02.012 |
| Popis: | ABSTRACT: New groups of high-grade neuroepithelial tumours (HGNET) have emerged from the reclassification of central nervous system (CNS) embryonal tumours that have recognised CNS HGNET with BCOR alteration (CNS HGNET-BCOR). We report a two-year, nine-month-old Omani boy who presented to the Royal Hospital, Muscat, Oman, in 2015 with subacute head tilting and neck pain. A well-defined cerebellar lesion was found and he was treated with standard chemoradiotherapy. After a relapse at the age of five years, molecular testing revealed a BCOR alteration. He was treated with further surgery and high-dose chemotherapy; unfortunately, he relapsed and died three years after he was diagnosed. Keywords: Neuroepithelial Tumor; Glioblastoma; Human BCOR Protein; Embryonal Tumors; Case Report; Oman. |
| Databáze: | Directory of Open Access Journals |
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