Dissemination and genome characterization of a human adenovirus F41 in a patient with B-Cell lymphoma

Autor:	Amary Fall, Victoria L. Campodónico, Craig Howard, Nicholas Gallagher, Gabrielle Bailey, Adriana E. Kajon, Heba H. Mostafa
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Adenovirus F41 Dissemination B-cell lymphoma Genome characterization Infectious and parasitic diseases RC109-216
Zdroj:	Virology Journal, Vol 20, Iss 1, Pp 1-5 (2023)
Druh dokumentu:	article
ISSN:	1743-422X
DOI:	10.1186/s12985-023-02101-3
Popis:	Abstract Adenovirus (HAdV) F41 is a common cause of gastroenteritis and has rarely been reported associated with disseminated disease. In this report, an adult patient with a history of ulcerative colitis, cryptogenic cirrhosis, stage III adenocarcinoma, high-grade diffuse large B-cell lymphoma on chemotherapy was diagnosed with disseminated adenovirus infection. HAdV DNA was quantified in stool, plasma, and urine with viral loads of 7, 4, and 3 log10 copies/mL, respectively. The patient’s course was rapidly progressive and he passed away 2 days after initiation of antiviral therapy. The patient’s infecting virus was characterized as HAdV-F41 by whole genome sequencing.
Databáze:	Directory of Open Access Journals
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