Assesment of Superior Colliculus in Audiogenic Epilepsy-Prone Wistar Rats Using A Stereological Method

Autor: Seval KELOĞLAN, Niyazi TAŞÇI, Süleyman KAPLAN, Cafer MARANGOZ
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Archives of Epilepsy, Vol 23, Iss 1, Pp 7-12 (2017)
Druh dokumentu: article
ISSN: 2792-0550
DOI: 10.14744/epilepsi.2016.48802
Popis: Objectives:Audiogenic seizures are generated in the brainstem and involve the inferior and superior colliculi in their expression. Aim of the present study was to estimate total number of neurons in the right and left superior colliculi in genetically audiogenic epilepsy-prone Wistar rats using stereological method.Methods:Ten female Wistar rats, weighing 180 to 220 g each, were divided into 2 groups: control (n=5) and audiogenic epilepsy (n=5) groups. Subjects were anesthetized with urethane (1.25 g/kg, intraperitoneal) and 10% formalin was perfused through the left cardiac ventricle. Total number of neurons was estimated in the right and left superior colliculi in both groups using optical fractionator stereological method.Results:Total number of neurons in the superior colliculi was statistically lower in the right side of group with epilepsy compared with same side of control group (p
Databáze: Directory of Open Access Journals