Green Walnut Husk Ameliorating the Adverse Effects Induced by High Fat Diet in Rats
| Autor: | Sharif O Rozha, Farhad M Hawraz, Mahmud R Harseen, Ali H Hassan, Kanabi M Rebin, Hiewa O Dyary, Muhammed S Lava, Mazn M Soz |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | The Iraqi Journal of Veterinary Medicine, Vol 45, Iss 2 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1609-5693 2410-7409 |
| DOI: | 10.30539/ijvm.v45i2.1286 |
| Popis: | This study was designed to investigate the ameliorating effect of methanolic extract of green walnut husk (GWH) in hypercholesterolemic rats. A total of thirty male Albino Wistar rats (Rattus norvegicus domestica) were divided randomly into six equal groups. Group 1, negative control, fed on a standard rat diet whereas groups 2–6, hypercholesterolemic rats, fed a high-fat diet (1% cholesterol in a standard diet). Group 2, positive control, was left untreated, whereas the groups 3–5 treated orally with methanolic extract of GWH at 200, 400, and 800 mg/kg/day BW, respectively. Group 6, treatment control, received atorvastatin intraperitoneally at a dosage rate of 0.8 mg/kg/day. The treatment lasted for 84 days. Lipid profiles, biomarkers for liver and kidney functions, some hematological parameters, and liver histopathological assessment were performed. No significant variation was observed on lipid profile values after 42 days of GWH intake; while after 84 days, there was significant reduction (P |
| Databáze: | Directory of Open Access Journals |
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