Most common HCV genotypes in patients from north-eastern Croatia
| Autor: | Magdalena Perić, Zinka Bošnjak, Snježana Džijan, Bojan Šarkanj, Jerko Barbić, Ivana Roksandić Križan, Nataša Ružman, Vedran Bertić, Dubravka Vuković |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Acta Medica Academica, Vol 43, Iss 1, Pp 10-18 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1840-1848 1840-2879 |
| DOI: | 10.5644/ama2006-124.95 |
| Popis: | Objective. The aims of this study were to determine the HCV-RNA viral load, genotype distribution, risk factors and symptoms of HCVRNA positive viral load in HCV antibody-positive patients from north-eastern Croatia. Materials and methods. From January 2009 to December 2011, 203 HCV antibody- positive patients (130 men and 73 women; median age 44.5 years) were analyzed for HCV-RNA by the COBAS TaqMan HCV test and genotyped by the Linear Array HCV Genotyping test (both from Roche). All patients completed a structured questionnaire about risk factors and symptoms. Results. The HCV-RNA percentage was 61.1% and was similar for men and women. The HCV-RNA viral load increased with age: while 55% of 20-50 year old patients were HCV-RNA positive, 73% of patients >50 years were positive (p=0.021). Genotype 1 was the most prevalent genotype (79.8%), followed by 3 (12.9%), 4 (6.5%), and 2 (0.8%); genotypes 5 and 6 were not determined. Patients with genotype 1 (median, 50 years) were older than patients with 3 (median, 33.5 years) or 4 (median, 38 years). The blood transfusions performed in Croatian hospitals before 1993 was significantly associated with HCV-RNA positive viral load (p |
| Databáze: | Directory of Open Access Journals |
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