T Cell Responses Correlate with Self-Reported Disease Severity and Neutralizing Antibody Responses Predict Protection against SARS-CoV-2 Breakthrough Infection

Autor: Zhen Zhao, Attila Kumanovics, Tanzy Love, Stacy E. F. Melanson, Qing H. Meng, Alan H. B. Wu, Joesph Wiencek, Fred S. Apple, Caitlin R. Ondracek, David D. Koch, Robert H. Christenson, Yan Victoria Zhang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Viruses, Vol 15, Iss 3, p 709 (2023)
Druh dokumentu: article
ISSN: 15030709
1999-4915
DOI: 10.3390/v15030709
Popis: Objectives: The objective of this prospective study was to investigate the role of adaptive immunity in response to SARS-CoV-2 vaccines. Design and Methods: A cohort of 677 vaccinated individuals participated in a comprehensive survey of their vaccination status and associated side effects, and donated blood to evaluate their adaptive immune responses by neutralizing antibody (NAb) and T cell responses. The cohort then completed a follow-up survey to investigate the occurrence of breakthrough infections. Results: NAb levels were the highest in participants vaccinated with Moderna, followed by Pfizer and Johnson & Johnson. NAb levels decreased with time after vaccination with Pfizer and Johnson & Johnson. T cell responses showed no significant difference among the different vaccines and remained stable up to 10 months after the study period for all vaccine types. In multivariate analyses, NAb responses (
Databáze: Directory of Open Access Journals
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