Association between routine biomarkers and atrial fibrillation in patients undergoing implantation of a dual‐chamber pacemaker

Autor: Konstantinos Kyrlas, Tong Liu, George Bazoukis, Sofia Plakoutsi, Evangelos Liberopoulos, Haralampos Milionis, Panagiotis Korantzopoulos
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Arrhythmia, Vol 37, Iss 1, Pp 219-225 (2021)
Druh dokumentu: article
ISSN: 1883-2148
1880-4276
DOI: 10.1002/joa3.12479
Popis: Abstract Background Elderly patients having a permanent pacemaker frequently have atrial remodeling. We examined the association between routine biomarkers and atrial fibrillation (AF) in patients receiving a dual‐chamber pacemaker for sinus node disease (SND) or second‐/third‐degree atrioventricular block. Methods We recorded clinical, laboratory, and electrocardiographic parameters as well as pacemaker lead parameters at implantation. The final analysis included 217 patients with SND and 393 patients with atrioventricular block. Notably, 102/217 (47%) of the SND patients (median age: 77 years, 54% men) and 54/393 (14%) of the atrioventricular block patients (median age: 79 years, 54% men) had AF history (paroxysmal or persistent). Results Multivariable analysis showed that red blood cell distribution width (RDW) (OR: 1.17; 95% CI: 1.05‐1.36; P = .05) and serum γ‐glutamyl transferase (γGT) levels (OR: 1.15; 95% CI: 1.03‐1.28; P = .04) were independently associated with AF history in patients with SND. In ROC curve analysis, the area under the curve (AUC) was 0.648; P
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