| Autor: |
Zi-Yi Zhou, Tian-Fang Chang, Zhi-Bin Lin, Yu-Tong Jing, Li-Shi Wen, Ya-Li Niu, Qian Bai, Chang-Mei Guo, Jia-Xing Sun, Yu-Sheng Wang, Guo-Rui Dou |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Cell Death and Disease, Vol 14, Iss 6, Pp 1-15 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2041-4889 |
| DOI: |
10.1038/s41419-023-05897-8 |
| Popis: |
Abstract Microglia were considered as immune cells in inflammation until their angiogenic role was widely understood. Although the pro-inflammatory role of microglia in retinal angiogenesis has been explored, little is known about its role in pro-angiogenesis and the microglia–endothelia interaction. Here, we report that galectin-3 (Gal3) released by activated microglia functions as a communicator between microglia and endothelia and competitively binds to Jag1, thus inhibiting the Notch signaling pathway and enhancing endothelial angiogenic metabolism to promote angiogenesis. These results suggest that Gal3 may be a novel and effective target in the treatment of retinal angiogenesis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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