| Autor: |
Lana Y.M. Juee, Alaadin M. Naqishbandi |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 66, Iss , Pp 103821- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2020.103821 |
| Popis: |
Calabash fruit is traditionally used as an antidiabetic remedy in the Kurdistan region. Different extracts (400 mg/kg) were investigated for antihyperglycemic potency on normal and alloxan-induced diabetic mice. The significant potency exhibited by the aqueous extract produced a decrease in fasting blood glucose level (52.685%, P ≤ 0.05) in diabetic mice with no apparent effect using extracts in the normoglycemic model. The antihyperglycemic extract was evaluated for in vitro antidiabetic efficacy based on HepG2 cells, and the 2-NDBG indicator showed a significant glucose uptake (164.87%, P ≤ 0.05), whereas the in vitro antioxidant study showed high ABTS free radical scavenging activity (EC50 64.4 ± 2.12 µg/mL). The extract phytochemical study recorded a high phenolic content with the identification of two compounds, protocatechuic acid, and luteolin-7-glucoside, using liquid chromatography-tandem mass spectrometry. The results revealed the benefits of the fruit in the reduction of hyperglycemia and attenuating oxidative stress associated with diabetes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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