Preoperative oral antibiotic prophylaxis reduces Pseudomonas aeruginosa surgical site infections after elective colorectal surgery: a multicenter prospective cohort study

Autor: A Gomila, J Carratalà, J M Badia, D Camprubí, M Piriz, E Shaw, V Diaz-Brito, E Espejo, C Nicolás, M Brugués, R Perez, A Lérida, A Castro, S Biondo, D Fraccalvieri, E Limón, F Gudiol, M Pujol, on behalf of VINCat Colon Surgery Group
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-9 (2018)
Druh dokumentu: article
ISSN: 1471-2334
DOI: 10.1186/s12879-018-3413-1
Popis: Abstract Background Healthcare-associated infections caused by Pseudomonas aeruginosa are associated with poor outcomes. However, the role of P. aeruginosa in surgical site infections after colorectal surgery has not been evaluated. The aim of this study was to determine the predictive factors and outcomes of surgical site infections caused by P. aeruginosa after colorectal surgery, with special emphasis on the role of preoperative oral antibiotic prophylaxis. Methods We conducted an observational, multicenter, prospective cohort study of all patients undergoing elective colorectal surgery at 10 Spanish hospitals (2011–2014). A logistic regression model was used to identify predictive factors for P. aeruginosa surgical site infections. Results Out of 3701 patients, 669 (18.1%) developed surgical site infections, and 62 (9.3%) of these were due to P. aeruginosa. The following factors were found to differentiate between P. aeruginosa surgical site infections and those caused by other microorganisms: American Society of Anesthesiologists’ score III–IV (67.7% vs 45.5%, p = 0.001, odds ratio (OR) 2.5, 95% confidence interval (95% CI) 1.44–4.39), National Nosocomial Infections Surveillance risk index 1–2 (74.2% vs 44.2%, p
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