Neurospecific peptides in the assessment of brain damage in patients with atherothrombotic stroke
| Autor: | M. Yu. Maximova, V. G. Ionova, E. N. Syskina, A. A. Shabalina, M. V. Kostyreva, O. A. Sinektutova |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Анналы клинической и экспериментальной неврологии, Vol 5, Iss 3, Pp 4-10 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2075-5473 2409-2533 |
| DOI: | 10.17816/psaic303 |
| Popis: | Assessment of neurospecific peptides provide quantitative informationabout the severity of ischemic cell damage. We studied 26patients with atherothrombotic stroke. Control group comprised15 healthy volunteers. Each patient underwent neurologicalexamination and CT or MRI of the brain on admission. Patientswith documented or clinical evidence of nervous system tumor,brain infarction, hemorrhage, head trauma, or central nervoussystem infection within 3 months before admission were excludedfrom this study. Stroke severity was rated using the NationalInstitutes of Health Stroke Scale. S100 and NSE assays wereperformed using a radioimmunoassay technique. S100 and NSElevels were measured in cerebrospinal fluid (CSF) and serum.CSF and serum S100 and NSE levels were elevated in patientswith atherothrombotic stroke compared with the control group.Elevation of S100 and NSE levels in CSF and serum afterischemic stroke may be a result of combined leakage out ofnecrotic cells and passage through an impaired brain-blood barrier,indicating severe ischemic cell injury. |
| Databáze: | Directory of Open Access Journals |
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