Effectiveness assessment of sulfur-containing amino acids in rats with experimental 'alcohol withdrawal syndrome' with modified zoosocial interaction methods
| Autor: | V. I. Petrov, N. A. Osadchenko, A. S. Tarasov, A. M. Dotsenko, E. I. Morkovin |
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| Jazyk: | ruština |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Фармация и фармакология (Пятигорск), Vol 12, Iss 1, Pp 4-14 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2307-9266 2413-2241 |
| DOI: | 10.19163/2307-9266-2024-12-1-4-14 |
| Popis: | The aim of the work was to compare the effects of ademethionine, acetylcysteine and taurine on the zoosocial behavior of rats in a post-intoxicated state after an acute ethanol poisoning.Materials and methods. The study was conducted on male rats of the Wistar line. The post-intoxication state was modeled by a single injection of ethanol (3 g/kg, intraperitoneally). 30 min after awakening, the animals were injected with a physiological solution, acetylcysteine (1 g/kg), ademetionine (100 mg/kg) or taurine (40 mg/kg). A zoosocial interaction test was performed 30 min after the administration.Results. Among the behavioral indicators investigated, the following were validated: the number of acts of freezing, their duration, the number of acts of sniffing in front, the number of acts of avoidance and the number of vertical stances without support (p 0.05). Alcoholization reduced the number of vertical stances by 65% (p |
| Databáze: | Directory of Open Access Journals |
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