Nebulized vs. oral midazolam as a sedative premedication in pediatric anesthesia: A randomized controlled double-blinded study
| Autor: | Sherif Mohamed Soaida, Mohamed EL-Saied Hafez, Karim Kamal Girgis, Mohamed Mahmoud Marie, Mohamed Ahmed Selim |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Egyptian Journal of Anaesthesia, Vol 38, Iss 1, Pp 476-482 (2022) |
| Druh dokumentu: | article |
| ISSN: | 11101849 1110-1849 |
| DOI: | 10.1080/11101849.2022.2112063 |
| Popis: | Objective This study was carried out to compare different routes of midazolam administration (nebulized vs. oral) to achieve a satisfactory level of sedation, RAMSAY Sedation Score (RSS) of 4, within 30 minutes of midazolam administration in pediatric operative patients.Methods After approval of the ethical committee in Kasr Al-ainy university hospital and obtaining written consent from parents/legal guardians; Seventy-two pediatric patients scheduled for general and urological surgical operations under general anesthesia were included in this randomized double-blinded study. Patients were randomly assigned into one of the two equal groups. Group N: 36 children received nebulized midazolam 0.2 mg/kg in 3 ml normal saline plus 5 ml clear juice 30 min before undergoing general anesthesia (GA). Group O: 36 children received oral midazolam 0.5 mg/kg in 5 ml clear juice plus nebulizer of 3 ml normal saline 30 min before undergoing general anesthesia.Results We found no statistical difference between nebulized and oral midazolam regarding drug acceptance, peri-operative (sedation scores, hemodynamics, and side effects); P-value >0.05 for all values.Conclusion Nebulized midazolam is a good alternative to oral midazolam as a sedative premedication in pediatrics. |
| Databáze: | Directory of Open Access Journals |
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