Efficacy of artemether .. lumefantrine and artesunate-amodiaquine for treating uncomplicated falciparum malaria in children
| Autor: | Tri Faranita, Ayodhia Pitaloka Pasaribu, Muhammad Ali, Munar Lubis, Syahril Pasaribu |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Paediatrica Indonesiana, Vol 52, Iss 5, Pp 260-6 (2012) |
| Druh dokumentu: | article |
| ISSN: | 0030-9311 2338-476X |
| DOI: | 10.14238/pi52.5.2012.260-6 |
| Popis: | Background Artesunateamodiaquine (ASAQ) has been used as a firsdine treatment for uncomplicated faldparum malaria in Indonesia since 2004. Its efficacy depends on amodiaquine resistance of the infecting parasites. Artemetherlumefantrine (AL) has been shown to be highly efficacious in treating uncomplicated faldparum malaria in several countries. However, there have been few studies on these antimalarial medications in Indonesia. Objective To compare the efficacy of AL to ASAQ for treating uncomplicated faldparum malaria in children. Methods An open, randomized, controlled trial was conducted in schoolaged children in the Mandailing Natal Regency, North Sumatera Province, Indonesia, from October to December 2010. A total of 280 pediatric, uncomplicated falciparum malaria patients were randomly assigned to receive either AL or ASAQ for 3 days. Participants were followedup on days 1,2,3,7, 14, 28 and 42 following the first medication dose. The outcomes noted were adequate clinical and parasitological response (ACPR), parasite reduction, parasite clearance time, fever clearance time and adverse events. Analysis was based on intentiontotreat. Results In this study, ACPRs on day 42 were 86.4% and 90.7% for the ASAQ and AL groups, respectively (pO.260). On days 7 and 14, the AL group had higher cure rates than that of the ASAQ group (P |
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