STUDY OF PROTHROMBOTIC MOLECULES IN TYPE 1 DIABETES MELLITUS CHILDREN
| Autor: | Adela Victoria Abregú, Elba Irma Díaz, María Cristina Bazán, Mariano Nicolás Áleman, María Constanza Luciardi, Ana Carolina Mariani |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Revista de la Sociedad Argentina de Diabetes, Vol 53, Iss 2, Pp 70-75 (2019) |
| Druh dokumentu: | article |
| ISSN: | 0325-5247 2346-9420 |
| DOI: | 10.47196/diab.v53i2.153 |
| Popis: | Introduction: hyperglycemia contributes to molecular changes that alter hemostasis. Objectives: to determine molecules of a prothrombotic state in a child-juvenile population with type 1 diabetes (T1D), without clinical manifestation of vascular disease, and compare it with a control population. Patients and methods: thirty-five patients with T1D (11.0±2.5 years and 3.7±2.0 years of disease duration), without vascular complications and 20 healthy controls were studied. Plasma fibrinogen (Pf), plasminogen activator inhibitor 1 (PAI-1), von Willebrand factor antigen vWF:Ag and soluble CD40 ligand (sCD40L) and coagulation global tests such as platelet count, prothrombin time (PT), activated partial thromboplastin time (APTT) were determined. The data obtained were analized by Statistics SPSS 20 software and were expressed as the mean±standard desviation. Pearson coefficient was used to investigate correlations between variables. |
| Databáze: | Directory of Open Access Journals |
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