Validation of the Hepamet fibrosis score in a multi-ethnic Asian population

Autor: Shi-En Chong, Felicia Chang, Kee-Huat Chuah, Pavai Sthaneshwar, Nik Raihan Nik Mustapha, Sanjiv Mahadeva, Wah-Kheong Chan
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Annals of Hepatology, Vol 28, Iss 2, Pp 100888- (2023)
Druh dokumentu: article
ISSN: 1665-2681
DOI: 10.1016/j.aohep.2022.100888
Popis: Introduction and Objectives: The Hepamet fibrosis score was introduced for the diagnosis of advanced liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). To date, external validation is limited, and its utility in combination with liver stiffness measurement (LSM) has not been explored. Material and Methods: This is a cross-sectional study on NAFLD patients who had a liver biopsy and LSM on the same day. The diagnostic performance of the Hepamet fibrosis score was evaluated using the area under the receiver operating characteristic curve (AUROC). Results: The data for 196 patients were analyzed (mean age 50 ± 11 years old, 50% men, 56.6% Malay, 27.6% Chinese, 15.8% Indian, 67.9% NASH, 15.8% advanced liver fibrosis). The AUROC of Hepamet fibrosis score for the diagnosis of advanced liver fibrosis was 0.85 (95% CI, 0.80 – 0.91). Using the
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