Investigation of the association of Pro12Ala polymorphism in the PPARG gene with the occurence of obesity and metabolic syndrome in postmenopausal women

Autor: Pucar Aleksandra, Milanović Ana, Maksimović Nela, Filipović Tamara
Jazyk: English<br />Serbian
Rok vydání: 2024
Předmět:
Zdroj: Medicinski Podmladak, Vol 75, Iss 3, Pp 76-80 (2024)
Druh dokumentu: article
ISSN: 0369-1527
2466-5525
DOI: 10.5937/mp75-39771
Popis: Introduction: During menopause, the prevalence of metabolic disorders in women increases significantly. Postmenopausal women have increased waist circumference, high blood pressure, hypertriglyceridemia, hyperglycemia and low HDL cholesterol, which leads to an increased risk of cardiovascular events. Gamma gene PPAR-g belongs to the family of nuclear receptors and plays a significant role in lipid and glucose metabolism. Polymorphism Pro12Ala is present within the PPARG gene. The presence of the Ala allele leads to a 30 to 50% reduction in PPAR-g activity. Aim: The aim of the research is to determine the association between the genotype Pro12Ala polymorphism genotype in the PPAR-g gene and the metabolic syndrome, hypertension, as well as the biochemical parameters of obesity in postmenopausal women. Material and methods: Total of 98 female postmenopausal patients were included in the study. The analysis of Pro12Ala genotype of PPAR-g gene was done by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results: In the examined group of patients, CC (Pro/Pro) genotype was found in 81 patients (82.7%), while the CG (Pro/Ala) genotype was present in 17 patients (17.3%). Analysis of the association of Pro12Ala genotypes with the occurrence of metabolic syndrome, hypertension and type II diabetes showed that women carriers of CC genotype were statistically significantly more likely to have hypertension than carriers of CG genotype (p = 0.030). Analysis of the association of Pro12Ala polymorphisms with biochemical parameters (total cholesterol, HDL, LDL, triglycerides and glycaemia) did not show statistical significance. Conclusion: The results of this study indicate a possible association of the Pro/Pro genotype of the Pro12Ala polymorphism with the risk of developing hypertension in postmenopausal women.
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