Identification of multi-drug resistance gene (MDR1) in equine ileum
| Autor: | Cláudio Corrêa Natalini, Renata Lehn Linardi |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Ciência Rural, Vol 36, Iss 1, Pp 298-300 (2006) |
| Druh dokumentu: | article |
| ISSN: | 1678-4596 0103-8478 |
| DOI: | 10.1590/S0103-84782006000100048 |
| Popis: | P-glycoprotein (P-gp) is a membrane transporter encoded in the Multi-drug Resistance (MDR1) gene expressed in several normal tissues and over expressed in tumor cells. P-gp was already identified in different species but not yet in equine. MDR1 gene and P-gp are able to interfere with bioavailability and disposition of several drugs, altering pharmacokinetic and pharmacodinamic of drugs. The presence of the MDR1 and P-gp in the central nervous system blocks the entry of certain drugs in this tissue and reduces drug absorption and enhances drug elimination when P-gp and MDR1 are presented in the gastrointestinal tract. This study showed that the MDR1 gene is present in equine ileum. Future studies on the impact of the P-glycoprotein encoded gene MDR1 on drugs pharmacologic effects in horses are granted. |
| Databáze: | Directory of Open Access Journals |
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