Uncovering the expression patterns of chimeric transcripts using surveys of Affymetrix GeneChips

Autor: Rowsell Joanna, Camargo Renata da Silva, Langdon William B., Stalteri Maria A., Harrison Andrew P.
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Journal of Integrative Bioinformatics, Vol 7, Iss 3, Pp 300-330 (2010)
Druh dokumentu: article
ISSN: 1613-4516
DOI: 10.1515/jib-2010-137
Popis: Background: A chimeric transcript is a single RNA sequence which results from the transcription of two adjacent genes. Recent studies estimate that at least 4% of tandem human gene pairs may form chimeric transcripts. Affymetrix GeneChip data are used to study the expression patterns of tens of thousands of genes and the probe sequences used in these microarrays can potentially map to exotic RNA sequences such as chimeras.
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