| Autor: |
Marcela Daza, Sheryll Corchuelo, Johana Osorio, Luis Alberto Gómez, Edgar Parra, Ángela Alarcón, Marcela Mercado |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Clinical Infection in Practice, Vol 17, Iss , Pp 100219- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2590-1702 |
| DOI: |
10.1016/j.clinpr.2023.100219 |
| Popis: |
Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection during pregnancy is related with adverse maternal, fetal, and neonatal outcomes. Placental SARS-CoV-2 involvement may include various degrees of inflammation and malperfusion leading to diverse pregnancy complications. Methods: Placental, fetal and umbilical cord samples of three fetal demise cases that occurred in the context of maternal SARS-CoV-2 infections were analyzed. Cases were notified to the Colombian SARS-CoV-2 National Surveillance System. RT-PCR and immunohistochemistry (IHC) analysis were employed to identify potential tissue viral involvement. Results: RT-PCR and IHC confirmed the presence of viral genomes and antigens in placental and umbilical cord tissues. Histopathological analysis revealed findings consistent with placental malperfusion and inflammation. Conclusions: SARS-CoV-2 infection during pregnancy can lead to placental dysfunction and damage compromising fetal survival. Many questions regarding SARS-CoV-2 dynamics during pregnancy including placental physiopathology and in utero transmission are still pending definitive answers. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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