The added value of mammography in different age-groups of women with and without BRCA mutation screened with breast MRI

Autor: Suzan Vreemann, Jan C. M. van Zelst, Margrethe Schlooz-Vries, Peter Bult, Nicoline Hoogerbrugge, Nico Karssemeijer, Albert Gubern-Mérida, Ritse M. Mann
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Breast Cancer Research, Vol 20, Iss 1, Pp 1-12 (2018)
Druh dokumentu: article
ISSN: 1465-542X
DOI: 10.1186/s13058-018-1019-6
Popis: Abstract Background Breast magnetic resonance imaging (MRI) is the most sensitive imaging method for breast cancer detection and is therefore offered as a screening technique to women at increased risk of developing breast cancer. However, mammography is currently added from the age of 30 without proven benefits. The purpose of this study is to investigate the added cancer detection of mammography when breast MRI is available, focusing on the value in women with and without BRCA mutation, and in the age groups above and below 50 years. Methods This retrospective single-center study evaluated 6553 screening rounds in 2026 women at increased risk of breast cancer (1 January 2003 to 1 January 2014). Risk category (BRCA mutation versus others at increased risk of breast cancer), age at examination, recall, biopsy, and histopathological diagnosis were recorded. Cancer yield, false positive recall rate (FPR), and false positive biopsy rate (FPB) were calculated using generalized estimating equations for separate age categories (
Databáze: Directory of Open Access Journals
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