Associations between a normal-range free thyroxine concentration and ovarian reserve in infertile women undergoing treatment via assisted reproductive technology

Autor: Qiaoling Zhang, Dandan Zhang, Haoyuan Liu, Jinyun Fu, Li Tang, Meng Rao
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Reproductive Biology and Endocrinology, Vol 22, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 1477-7827
DOI: 10.1186/s12958-024-01226-6
Popis: Abstract Background Some recent studies have shown that female subclinical hypothyroidism (SCH) is associated with diminished ovarian reserve (DOR). In this study, we aimed to investigate whether serum-free thyroxine (fT4) concentrations within the reference range are associated with ovarian reserve in women. Methods This cross-sectional study included 4933 infertile women with normal-range fT4 concentrations who received assisted reproductive technology treatment in our clinic. The data of women in different fT4 concentration tertiles (namely 12–15.33, 15.34–18.67, and 18.68–22 pmol/L) were compared with ovarian reserve markers, namely the anti-Müllerian hormone (AMH) concentration, the antral follicle count (AFC), and the number of aspirated oocytes. The primary outcomes were the AMH concentration and the risk of DOR, diagnosed as an AMH concentration
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