| Autor: |
Glenn T. Werneburg, Scott D. Lundy, Daniel Hettel, Petar Bajic, Bradley C. Gill, Ava Adler, Sromona D. Mukherjee, Hadley M. Wood, Kenneth W. Angermeier, Daniel A. Shoskes, Aaron W. Miller |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-023-38750-1 |
| Popis: |
Abstract To understand differences between asymptomatic colonized and infected states of indwelling medical devices, we sought to determine penile prosthesis biofilm composition, microbe-metabolite interaction networks, and association with clinical factors. Patients scheduled for penile prosthesis removal/revision were included. Samples from swabbed devices and controls underwent next-generation sequencing, metabolomics, and culture-based assessments. Biofilm formation from device isolates was reconstituted in a continuous-flow stir tank bioreactor. 93% of 27 analyzed devices harbored demonstrable biofilm. Seven genera including Faecalibaculum and Jeotgalicoccus were more abundant in infected than uninfected device biofilms (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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