Mycobacterium chelonae-abscessus Complex Associated with Sinopulmonary Disease, Northeastern USA

Autor: Keith E. Simmon, Barbara A. Brown-Elliott, Perry G. Ridge, Jacob D. Durtschi, Linda Bridge Mann, E. Susan Slechta, Arnold G. Steigerwalt, Benjamin D. Moser, Anne M. Whitney, June M. Brown, Karl V. Voelkerding, Karin L. McGowan, Anne F. Reilly, Thomas J. Kirn, W. Ray Butler, Paul H. Edelstein, Richard J. Wallace, Cathy A. Petti
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Emerging Infectious Diseases, Vol 17, Iss 9, Pp 1692-1700 (2011)
Druh dokumentu: article
ISSN: 1080-6040
1080-6059
DOI: 10.3201/eid1709.101667
Popis: Members of the Mycobacterium chelonae-abscessus complex represent Mycobacterium species that cause invasive infections in immunocompetent and immunocompromised hosts. We report the detection of a new pathogen that had been misidentified as M. chelonae with an atypical antimicrobial drug susceptibility profile. The discovery prompted a multicenter investigation of 26 patients. Almost all patients were from the northeastern United States, and most had underlying sinus or pulmonary disease. Infected patients had clinical features similar to those with M. abscessus infections. Taxonomically, the new pathogen shared molecular identity with members of the M. chelonae-abscessus complex. Multilocus DNA target sequencing, DNA-DNA hybridization, and deep multilocus sequencing (43 full-length genes) support a new taxon for these microorganisms. Because most isolates originated in Pennsylvania, we propose the name M. franklinii sp. nov. This investigation underscores the need for accurate identification of Mycobacterium spp. to detect new pathogens implicated in human disease.
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje