MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

Autor: Giovanni Battista Migliori, Simon Tiberi, Alimuddin Zumla, Eskild Petersen, Jeremiah Muhwa Chakaya, Christian Wejse, Marcela Muñoz Torrico, Raquel Duarte, Jan Willem Alffenaar, H. Simon Schaaf, Ben J. Marais, Daniela Maria Cirillo, Riccardo Alagna, Adrian Rendon, Emanuele Pontali, Alberto Piubello, José Figueroa, Gabriella Ferlazzo, Alberto García-Basteiro, Rosella Centis, Dina Visca, Lia D’Ambrosio, Giovanni Sotgiu, T. Abu Arkub, O.W. Akkerman, A. Aleksa, E. Belilovski, E. Bernal, F-X. Blanc, M. Boeree, S. Borisov, J. Bruchfeld, J. Cadiñanos Loidi, J.A. Caminero, A.C. Carvalho, J.J. Cebrian Gallardo, Charalampos, E. Danila, L. Davies Forsman, J. Denholm, K. Dheda, R. Diel, S. Diktanas, C. Dobler, M. Enwerem, S. Esposito, N. Escobar Salinas, A. Filippov, B. Formenti, J.M. García García, D. Goletti, R. Gomez Rosso, G. Gualano, P. Isaakidis, A. Kaluzhenina, S. Koirala, L. Kuksa, H. Kunst, Y. Li, C. Magis-Escurra, V. Manfrin, S. Manga, K. Manika, V. Marchese, E. Martínez Robles, A. Maryandyshev, A. Matteelli, A. Mariani, J. Mazza-Stalder, F. Mello, L. Mendoza, A. Mesi, S. Miliauskas, H. Mustafa Hamdan, N. Ndjeka, M. Nieto Marcos, T.H.M. Ottenhoff, D.J. Palmero, F. Palmieri, A. Papavasileiou, M.C. Payen, A. Pontarelli, M. Pretti Dalcolmo, S. Quirós Fernandez, R. Romero, D. Rossato Silva, A.P. Santos, B. Seaworth, M. Sinitsyn, A. Skrahina, I. Solovic, A. Spanevello, M. Tadolini, C. Torres, Z. Udwadia, M. van den Boom, G.V. Volchenkov, A. Yedilbayev, R. Zaleskis, J.P. Zellweger
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 92, Iss , Pp S15-S25 (2020)
Druh dokumentu: article
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2020.01.042
Popis: The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts.The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines.After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities. Keywords: MDR-TB, XDR-TB, Diagnosis, Treatment, Prevention, Rehabilitation of sequelae
Databáze: Directory of Open Access Journals