Ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae accompanied hypermucoviscosity acquisition

Autor:	Yingyi Guo, Jiong Wang, Likang Yao, Yijing Wang, Yan Zhang, Chuyue Zhuo, Xu Yang, Feifeng Li, Jiahui Li, Baomo Liu, Nanhao He, Jiakang Chen, Shunian Xiao, Zhiwei Lin, Chao Zhuo
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Ceftazidime-avibactam resistance KPC Hypermucoviscosity wzc K. pneumoniae Microbiology QR1-502
Zdroj:	BMC Microbiology, Vol 24, Iss 1, Pp 1-12 (2024)
Druh dokumentu:	article
ISSN:	1471-2180
DOI:	10.1186/s12866-024-03508-w
Popis:	Abstract Background Antimicrobial resistance and bacterial hypermucoviscosity, associated with escalating production of capsules, constitute major challenges for the clinical management of Klebsiella pneumoniae (K. pneumoniae) infections. This study investigates the association and underlying mechanism between ceftazidime-avibactam (CAZ-AVI) resistance and bacterial hypermucoviscosity in Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-Kp). Results The proportion of CAZ-AVI-sensitive clinical isolates exhibiting the hypermucoviscous phenotype was significantly lower than that of the resistant strains (5.6% vs. 46.7%, P
Databáze:	Directory of Open Access Journals
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