Lactose intolerance and levothyroxine malabsorption: a review of the literature and report of a series of patients treated with liquid L-T4 without lactose
| Autor: | Silvia Martina Ferrari, Armando Patrizio, Valeria Mazzi, Francesca Ragusa, Chiara Botrini, Giusy Elia, Eugenia Balestri, Emilio Barozzi, Licia Rugani, Fabiana Bracchitta, Giulio Stoppini, Giada Frenzilli, Enke Baldini, Camilla Virili, Salvatore Benvenga, Poupak Fallahi, Alessandro Antonelli |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Frontiers in Endocrinology, Vol 15 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1664-2392 00416398 |
| DOI: | 10.3389/fendo.2024.1386510 |
| Popis: | In hypothyroid patients needing large doses of levothyroxine (L-T4) (>1.7–2 μg/kg/day) to reach euthyroidism, lactose intolerance (LI) needs to be excluded, owing to the high prevalence in the population. If LI is present, a lactose-free diet decreases the rate of L-T4 malabsorption. However, an increased requirement of L-T4 is described in patients with LI, which can be beneficially treated using lactose-free L-T4 formulation. The lactose-free liquid L-T4 formulation is able to circumvent LI malabsorption leading to the normalization of thyroid-stimulating hormone (TSH) in patients with subclinical hypothyroidism and long-term stable TSH levels. |
| Databáze: | Directory of Open Access Journals |
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