| Autor: |
Liting You, Ruizhan Tong, Mengqian Li, Yuncong Liu, Jianxin Xue, You Lu |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 359-370 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2329-0501 |
| DOI: |
10.1016/j.omtm.2019.02.008 |
| Popis: |
The expanding CRISPR-Cas9 technology is an easily accessible, programmable, and precise gene-editing tool with numerous applications, most notably in biomedical research. Together with advancements in genome and transcriptome sequencing in the era of metadata, genomic engineering with CRISPR-Cas9 meets the developmental requirements of precision medicine, and clinical tests using CRISPR-Cas9 are now possible. This review summarizes developments and established preclinical applications of CRISPR-Cas9 technology, along with its current challenges, and highlights future applications in translational research. Keywords: CRISPR-Cas9, gene editing, off-target, gene therapy, tumor immunotherapy |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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