6-Cyclohexylmethyl-2-cyclohexylsulfanyl-5-isopropylpyrimidin-4(3H)-one
| Autor: | Cong Li, Yan-Ping He, De-Hua Zhang, Da-Xiong Li, Chun-Sheng Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Acta Crystallographica Section E, Vol 64, Iss 9, Pp o1768-o1768 (2008) |
| Druh dokumentu: | article |
| ISSN: | 16005368 1600-5368 82731845 |
| DOI: | 10.1107/S1600536808025592 |
| Popis: | The title compound, C20H32N2OS, was obtained during the course of our investigation on 2-alkylsulfanyl-6-benzyl-3,4-dihydropyrimidin-4(3H)-ones (S–DABOs) showing favourable anti-HIV-1 activity. Both cyclohexane rings adopt chair conformations. The angle at the methylene C atom linking the pyrimidine and cyclohexane ring is 113.7 (3)°, which is in the range considered optimal for maximum activity of non-nucleoside reverse transcriptase inhibitors. Intermolecular N—H...O hydrogen bonds link the molecules into dimers and stabilize the crystal structure of the compound. In addition, an intramolecular C—H...O hydrogen bond is observed. |
| Databáze: | Directory of Open Access Journals |
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