Using Glucose Tolerance Tests to Model Insulin Secretion and Clearance

Autor:	Anthony Shannon
Jazyk:	angličtina
Rok vydání:	2005
Předmět:	Compartment modelling Differential equations Technetium Diabetes mellitus Glucose tolerance tests Gamma variate Biotechnology TP248.13-248.65 Biology (General) QH301-705.5
Zdroj:	Bioautomation, Vol 2, Iss 1, Pp 93-106 (2005)
Druh dokumentu:	article
ISSN:	1313-261X 1312-451X
Popis:	The purpose of the studies described in this paper is to develop theoretically and to validate experimentally mathematical compartment models which can be used to predict plasma insulin levels in patients with diabetes mellitus (DM). In the case of Type 2 Diabetes Mellitus (T2DM), the C-peptide levels in the plasma were measured as part of routine glucose tolerance tests in order to estimate the prehepatic insulin secretion rates. In the case of Type 1 Diabetes Mellitus (T1DM), a radioactive labelled insulin was used to measure the absorption rate of insulin after a subcutaneous injection of insulin. Both models gave close fits between theoretical estimates and experimental data, and, unlike other models, it is not necessary to seed these models with initial estimates.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5ba79fc2b7b34b4f9d6368e8e4d5ac9b Zobrazit plný text záznamu View record in DOAJ