Comparison between Topical Platelet-rich Plasma and Normal Saline Dressing in Conjunction with Total Contact Casting in Treatment of Diabetic Foot Ulcer – A Randomised Control Trial

Autor: Subha Das, Anjani Kumar, Sanyal Kumar, Sanjay Kumar Pandey, Niraj Kumar, Ranjeet Kumar
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Indian Journal of Physical Medicine & Rehabilitation, Vol 34, Iss 3, Pp 212-217 (2024)
Druh dokumentu: article
ISSN: 0973-2209
2949-8058
DOI: 10.4103/ijpmr.ijpmr_43_24
Popis: Introduction: Effective wound care is crucial in managing diabetic foot ulcers (DFU), with practices such as wound cleaning and maintaining moisture being essential. The total-contact cast (TCC) is a recognized and effective method for off-loading plantar ulcers. This study compares the effectiveness of platelet-rich plasma (PRP) and normal saline (NS) dressings, both combined with TCC, in the treatment of DFUs. Methods: A total of 108 patients with diabetic foot ulcers were randomly divided into three groups: PRP, NS, and TCC, with 36 patients in each group. The PRP group received autologous PRP followed by TCC application, the NS group received wet NS dressings followed by TCC application, and the TCC group had TCC alone. Patients were followed every 15 days for 90 days, with wound measurements taken and TCC reapplied at each visit. Wound healing was assessed based on the time to heal and the PUSH score. Results: Baseline wound sizes were similar across groups, but by day 90, the PRP group showed a greater reduction in wound size (0.61±1.20) compared to the NS (1.58±1.55) and TCC groups (1.22±1.34). The PRP group also had the most significant improvement in PUSH scores, indicating superior wound healing. Conclusion: PRP, NS, and TCC are all effective in DFU treatment, but PRP combined with TCC is statistically superior in enhancing wound healing and reducing the frequency of hospital visit.
Databáze: Directory of Open Access Journals
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