| Autor: |
Guilherme Arraché Gonçalves, Flávio Castro do Nascimento, Sidnei Moura e Silva, Cristiano Valim Bizarro, Luiz Augusto Basso, Pablo Machado |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Results in Chemistry, Vol 4, Iss , Pp 100539- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2211-7156 |
| DOI: |
10.1016/j.rechem.2022.100539 |
| Popis: |
N-phenethylquinazolin-4-amines have emerged as potential Mycobacterium tuberculosis cytochrome bd oxidase inhibitors and attractive scaffolds in tuberculosis drug discovery programs. The classical two-step strategy of chlorination-amination to synthesize such structures presents several operational issues accompanied by variable results. This work reports an efficient one-pot protocol to access N-phenethylquinazolin-4-amines via silylation-amination mediated by hexamethyldisilazane. The products were obtained with excellent yields (84–99%) under one-pot solvent-free conditions. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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