| Autor: |
Ganesh N. Sharma, Manmohan Singhal, Mathew George, Shailly Gupta, Vikas Garg |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Journal of Advanced Pharmaceutical Technology & Research, Vol 1, Iss 1, Pp 68-77 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
0976-2094 |
| Popis: |
This work has been done for the investigation of the anti-inflammatory andanalgesic activity of methanol extract of dried leaves of Murraya koenigii Linn by oraladministration at dose of 100, 200 and 400 mg/kg body weight, to healthy animals.Extract was studied for its anti-inflammatory activity by using carrageenan-induced hindpaw edema in albino rats and the mean increase in paw volume and % inhibition in pawvolume were measured plethysmometrically at different time intervals after carrageenan(1% w/v) injection. Extract was also evaluated for analgesic activity using Eddy’s hotplate method and formalin induced paw licking method in albino rats. The methanolextract showed significant (P < 0.001) reduction in the carrageenan-induced paw edemaand analgesic activity evidenced by increase in the reaction time by eddy’s hot platemethod and percentage increase in pain in formalin test. The methanol extract showedanti-inflammatory and analgesic effect in dose dependent manner when compared withthe control and standard drug, diclofenac sodium (10mg/kg, p.o). These inhibitions werestatistically significant (P < 0.05). Thus our investigation suggests a potential benefit ofMurraya koenigii in treating conditions associated with inflammatory pain. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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