Effect of modest caloric restriction on oxidative stress in women, a randomized trial.
| Autor: | Maciej S Buchowski, Nobuko Hongu, Sari Acra, Li Wang, Joshua Warolin, L Jackson Roberts |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | PLoS ONE, Vol 7, Iss 10, p e47079 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1932-6203 14728990 |
| DOI: | 10.1371/journal.pone.0047079 |
| Popis: | ObjectivesIt is not established to what extent caloric intake must be reduced to lower oxidative stress in humans. The aim of this study was to determine the effect of short-term, moderate caloric restriction on markers of oxidative stress and inflammation in overweight and obese premenopausal women.Materials/methodsRandomized trial comparison of 25% caloric restriction (CR) or control diet in 40 overweight or obese women (body mass index 32±5.8 kg/m(2)) observed for 28 days and followed for the next 90 days. Weight, anthropometry, validated markers of oxidative stress (F(2)-isoprostane) and inflammation (C-reactive protein), adipokines, hormones, lipids, interleukins, and blood pressure were assessed at baseline, during the intervention, and at follow-up.ResultsBaseline median F(2)-isoprostane concentration (57.0, IQR = 40.5-79.5) in the CR group was 1.75-fold above average range for normal weight women (32.5 pg/ml). After starting of the caloric restriction diet, F(2)-isoprostane levels fell rapidly in the CR group, reaching statistical difference from the control group by day 5 (median 33.5, IQR = 26.0-48.0, PConclusionsOxidative stress can be rapidly reduced and sustained through a modest reduction in caloric intake suggesting potential health benefits in overweight and obese women.Trial registrationClinicaltrials.gov NCT00808275. |
| Databáze: | Directory of Open Access Journals |
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