The Efficacy and Safety of Moderate-Intensity Rosuvastatin with Ezetimibe versus High-Intensity Rosuvastatin in High Atherosclerotic Cardiovascular Disease Risk Patients with Type 2 Diabetes Mellitus: A Randomized, Multicenter, Open, Parallel, Phase 4 Study

Autor:	Jun Sung Moon, Il Rae Park, Sang Soo Kim, Hye Soon Kim, Nam Hoon Kim, Sin Gon Kim, Seung Hyun Ko, Ji Hyun Lee, Inkyu Lee, Bo Kyeong Lee, Kyu Chang Won
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	cardiovascular diseases diabetes mellitus type 2 drug therapy combination ezetimibe rosuvastatin calcium Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	Diabetes & Metabolism Journal, Vol 47, Iss 6, Pp 818-825 (2023)
Druh dokumentu:	article
ISSN:	2233-6079 2233-6087 86445618
DOI:	10.4093/dmj.2023.0171
Popis:	Background To investigate the efficacy and safety of moderate-intensity rosuvastatin/ezetimibe combination compared to highintensity rosuvastatin in high atherosclerotic cardiovascular disease (ASCVD) risk patients with type 2 diabetes mellitus (T2DM). Methods This study was a randomized, multicenter, open, parallel phase 4 study, and enrolled T2DM subjects with an estimated 10-year ASCVD risk ≥7.5%. The primary endpoint was the low-density lipoprotein cholesterol (LDL-C) change rate after 24-week rosuvastatin 10 mg/ezetimibe 10 mg treatment was non-inferior to that of rosuvastatin 20 mg. The achievement proportion of 10-year ASCVD risk
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ee5b88b0f8644561866af9578c3934b8 Zobrazit plný text záznamu View record in DOAJ