Genetic susceptibility to airway inflammation and exposure to short-term outdoor air pollution

Autor:	Femke Bouma, Fredrik Nyberg, Anna-Carin Olin, Hanne Krage Carlsen
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Gene-environment interaction Short-term air pollution exposure Airway inflammation FeNO Quantile regression Industrial medicine. Industrial hygiene RC963-969 Public aspects of medicine RA1-1270
Zdroj:	Environmental Health, Vol 22, Iss 1, Pp 1-12 (2023)
Druh dokumentu:	article
ISSN:	1476-069X
DOI:	10.1186/s12940-023-00996-7
Popis:	Abstract Background Air pollution is a large environmental health hazard whose exposure and health effects are unequally distributed among individuals. This is, at least in part, due to gene-environment interactions, but few studies exist. Thus, the current study aimed to explore genetic susceptibility to airway inflammation from short-term air pollution exposure through mechanisms of gene-environment interaction involving the SFTPA, GST and NOS genes. Methods Five thousand seven hundred two adults were included. The outcome measure was fraction of exhaled nitric oxide (FeNO), at 50 and 270 ml/s. Exposures were ozone (O3), particulate matter
Databáze:	Directory of Open Access Journals
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